Being totally sedentary is as toxic as smoking 10 cigarettes a day.

Does your body's existence involve going from your bed to the chair, then from the elevator to your car, from your office chair to a chair in a restaurant,... then in the evening back to the dining room table, then the sofa with a TV tray and remote control? If this classic scenario is at all familiar to you, then you are truly a sedentary person! Don't tell yourself "I'm as normal as all my friends, neighbors and colleagues and they live like me". Try not to be a sedentary person who is living below their full potential. For physical, metabolic and psychological reasons, being so sedentary is toxic and as dangerous and harmful to your health as smoking 10 cigarettes a day. To get out of this state and its risks, all you have to do is stand up for one hour per day or walk for 20 minutes.

References:

http://www.dukandiet.com/weight-loss-secrets/get-moving